Doxorubicin Chronic Cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Inorganic Nitrate Therapy Improves Doxorubicin-Induced Cardiomyopathy
The anthracycline doxorubicin (DOX) is a potent and effective antineoplastic antibiotic agent widely used in the treatment of a broad range of forms of cancer. The clinical use of DOX is limited by cardiotoxicity, which increases dose dependently and may lead to dilated cardiomyopathy and clinical manifestations of congestive heart failure up to 10 to 15 years after the cessation of DOX chemoth...
متن کاملBovine Model of Doxorubicin-Induced Cardiomyopathy
Left ventricular assist devices (LVADs) constitute a recent advance in heart failure (HF) therapeutics. As the rigorous experimental assessment of LVADs in HF requires large animal models, our objective was to develop a bovine model of cardiomyopathy. Male calves (n = 8) were used. Four animals received 1.2 mg/kg intravenous doxorubicin weekly for seven weeks and four separate animals were stud...
متن کاملCarvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy.
Several cytopathic mechanisms have been suggested to mediate the dose-limiting cumulative and irreversible cardiomyopathy caused by doxorubicin. Recent evidence indicates that oxidative stress and mitochondrial dysfunction are key factors in the pathogenic process. The objective of this investigation was to test the hypothesis that carvedilol, a nonselective beta-adrenergic receptor antagonist ...
متن کاملTime-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy.
BACKGROUND Doxorubicin causes a chronic cardiomyopathy of unknown pathogenesis. We investigated whether acquired defects in mitochondrial DNA (mtDNA) and interconnected respiratory chain dysfunction may represent a molecular mechanism for its late onset. METHODS AND RESULTS Rats were treated weekly with intravenous doxorubicin (1 mg/kg) for 7 weeks, starting at 11 weeks of age (group B). Cont...
متن کاملan ovine model of dilated cardiomyopathy induced by doxorubicin
background: dilated cardiomyopathy is associated with a progressive deterioration in cardiac function and eventually death. initial interest in this hypothesis was to create another large animal model for dilated cardiomyopathy in addition to pigs and dogs . methods: after the induction of anesthesia to 10 female sheep, a carotid-jugular shunt was created in all the animals via a 1-cm fistula b...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2017
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2017.11929627